Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease

Sepehr Bahadorani; Arthur J. Hilliker

doi:10.1139/G08-012

Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease

Sepehr Bahadorani, Arthur J. Hilliker

Producción científica: Article › revisión exhaustiva

14 Citas (Scopus)

Resumen

Substantial evidence suggests that antioxidants may play a major role in delaying the progress of Huntington's disease (HD). Here we investigated the effects of superoxide dismutase (cytoplasmic Cu/ZnSOD and mitochondrial MnSOD) and supplementation with dietary antioxidants (α-tocopherol and coenzyme Q10) on survival to adulthood in a Drosophila melanogaster model of HD. Our results illustrate that neither overexpression of superoxide dismutase nor supplementation of dietary antioxidants can rescue the lethal phenotype of HD flies. We discuss these results in conjunction with other evidence that antioxidants may only avert the oxidative stress induced progression of HD.

Idioma original	English (US)
Páginas (desde-hasta)	392-395
Número de páginas	4
Publicación	Genome
Volumen	51
N.º	5
DOI	https://doi.org/10.1139/G08-012
Estado	Published - may 2008
Publicado de forma externa	Sí

ASJC Scopus subject areas

Genetics
Molecular Biology
Biotechnology

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AB - Substantial evidence suggests that antioxidants may play a major role in delaying the progress of Huntington's disease (HD). Here we investigated the effects of superoxide dismutase (cytoplasmic Cu/ZnSOD and mitochondrial MnSOD) and supplementation with dietary antioxidants (α-tocopherol and coenzyme Q10) on survival to adulthood in a Drosophila melanogaster model of HD. Our results illustrate that neither overexpression of superoxide dismutase nor supplementation of dietary antioxidants can rescue the lethal phenotype of HD flies. We discuss these results in conjunction with other evidence that antioxidants may only avert the oxidative stress induced progression of HD.

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KW - Oxidative stress

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Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease

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