Antioxidant and hepatoprotective effects of Rosa damascena

C. R. Achuthan; B. H. Babu; Jose Padikkala

doi:10.1076/phbi.41.5.357.15945

Antioxidant and hepatoprotective effects of Rosa damascena

C. R. Achuthan
, B. H. Babu
, Jose Padikkala

Producción científica: Article › revisión exhaustiva

115 Citas (Scopus)

Resumen

The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl₄. This indicated that R. damascena could protect against CCl ₄ induced hepatotoxicity, possibly by its free radical scavenging activity.

Idioma original	English (US)
Páginas (desde-hasta)	357-361
Número de páginas	5
Publicación	Pharmaceutical Biology
Volumen	41
N.º	5
DOI	https://doi.org/10.1076/phbi.41.5.357.15945
Estado	Published - ago 2003
Publicado de forma externa	Sí

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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title = "Antioxidant and hepatoprotective effects of Rosa damascena",

abstract = "The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50\% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity.",

keywords = "Alkaline phosphatase, Antioxidant, Glutamine oxaloacetate transaminase, Glutamine pyruvate transaminase, Hepatoprotection, Hydroxyl radical, Lipid peroxidation, Superoxide radical",

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AU - Achuthan, C. R.

AU - Babu, B. H.

AU - Padikkala, Jose

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N2 - The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity.

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KW - Alkaline phosphatase

KW - Antioxidant

KW - Glutamine oxaloacetate transaminase

KW - Glutamine pyruvate transaminase

KW - Hepatoprotection

KW - Hydroxyl radical

KW - Lipid peroxidation

KW - Superoxide radical

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DO - 10.1076/phbi.41.5.357.15945

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SP - 357

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Antioxidant and hepatoprotective effects of Rosa damascena

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ASJC Scopus subject areas

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