Antineoplastic diterpene-benzoate macrolides from the fijian red alga Callophycus serratus

Julia Kubanek; Anne C. Prusak; Terry W. Snell; Rachel A. Giese; Kenneth I. Hardcastle; Craig R. Fairchild; William Aalbersberg; Carmen Raventos-Suarez; Mark E. Hay

doi:10.1021/ol052121f

Antineoplastic diterpene-benzoate macrolides from the fijian red alga Callophycus serratus

Julia Kubanek, Anne C. Prusak, Terry W. Snell, Rachel A. Giese, Kenneth I. Hardcastle, Craig R. Fairchild, William Aalbersberg, Carmen Raventos-Suarez, Mark E. Hay

Producción científica: Article › revisión exhaustiva

77 Citas (Scopus)

Resumen

(Chemical Equation Presented) Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

Idioma original	English (US)
Páginas (desde-hasta)	5261-5264
Número de páginas	4
Publicación	Organic Letters
Volumen	7
N.º	23
DOI	https://doi.org/10.1021/ol052121f
Estado	Published - nov 10 2005
Publicado de forma externa	Sí

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "(Chemical Equation Presented) Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.",

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T1 - Antineoplastic diterpene-benzoate macrolides from the fijian red alga Callophycus serratus

AU - Kubanek, Julia

AU - Prusak, Anne C.

AU - Snell, Terry W.

AU - Giese, Rachel A.

AU - Hardcastle, Kenneth I.

AU - Fairchild, Craig R.

AU - Aalbersberg, William

AU - Raventos-Suarez, Carmen

AU - Hay, Mark E.

PY - 2005/11/10

Y1 - 2005/11/10

N2 - (Chemical Equation Presented) Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

AB - (Chemical Equation Presented) Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

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Antineoplastic diterpene-benzoate macrolides from the fijian red alga Callophycus serratus

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