Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann; Gordon Ramage; Kacy VandeWalle; Thomas F. Patterson; Brian L. Wickes; José L. López-Ribot

doi:10.1128/AAC.47.11.3657-3659.2003

Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann
, Gordon Ramage
, Kacy VandeWalle
, Thomas F. Patterson
, Brian L. Wickes
, José L. López-Ribot

Producción científica: Article › revisión exhaustiva

88 Citas (Scopus)

Resumen

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

Idioma original	English (US)
Páginas (desde-hasta)	3657-3659
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	47
N.º	11
DOI	https://doi.org/10.1128/AAC.47.11.3657-3659.2003
Estado	Published - nov 2003

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

Acceder al documento

10.1128/AAC.47.11.3657-3659.2003

Otros archivos y enlaces

Citar esto

@article{0941d16f6aa045c399f86747e9011810,

title = "Antifungal Combinations against Candida albicans Biofilms In Vitro",

abstract = "Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.",

author = "Bachmann, \{Stefano P.\} and Gordon Ramage and Kacy VandeWalle and Patterson, \{Thomas F.\} and Wickes, \{Brian L.\} and L{\'o}pez-Ribot, \{Jos{\'e} L.\}",

year = "2003",

month = nov,

doi = "10.1128/AAC.47.11.3657-3659.2003",

language = "English (US)",

volume = "47",

pages = "3657--3659",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Antifungal Combinations against Candida albicans Biofilms In Vitro

AU - Bachmann, Stefano P.

AU - Ramage, Gordon

AU - VandeWalle, Kacy

AU - Patterson, Thomas F.

AU - Wickes, Brian L.

AU - López-Ribot, José L.

PY - 2003/11

Y1 - 2003/11

N2 - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

AB - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

UR - https://www.scopus.com/pages/publications/0242322572

UR - https://www.scopus.com/pages/publications/0242322572#tab=citedBy

U2 - 10.1128/AAC.47.11.3657-3659.2003

DO - 10.1128/AAC.47.11.3657-3659.2003

M3 - Article

C2 - 14576141

AN - SCOPUS:0242322572

SN - 0066-4804

VL - 47

SP - 3657

EP - 3659

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 11

ER -

Antifungal Combinations against Candida albicans Biofilms In Vitro

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto