Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis

Virgilo A. Salvo, Stephen M. Boué, Juan P. Fonseca, Steven Elliott, Cynthia Corbitt, Bridgette M. Collins-Burow, Tyler J. Curiel, Sudesh K. Srivastav, Betty Y. Shih, Carol Carter-Wientjes, Charles E. Wood, Paul W. Erhardt, Barbara S. Beckman, John A. McLachlan, Thomas E. Cleveland, Matthew E. Burow

Resultado de la investigación: Articlerevisión exhaustiva

101 Citas (Scopus)


Purpose: We have identified the phytoalexin compounds glyceollins I, II, and III, which exhibit marked antiestrogenic effects on estrogen receptor function and estrogen-dependent tumor growth in vivo. The purpose of this study was to investigate the interactions among the induced soy phytoalexins glyceollins I, II. and III on the growth of estrogen-dependent MCF-7 breast cancer and BG-1 ovarian cancer cells implanted in ovariectomized athymic mice. Experimental Design: Four treatment groups for each cell line were used: vehicle control, 20 mg/kg/mouse/d glyceollin mixture injection, 0.72 mg estradiol (E2) implant, and E2 implant + 20 mg/kg/mouse/d glyceollin injection. Results: Treatment with glyceollin suppressed E2-stimulated tumor growth of MCF-7 cells (-53.4%) and BG-1 cells (-73.1%) in ovariectomized athymic mice. These tumor-inhibiting effects corresponded with significantly lower E2-induced progesterone receptor expression in the tumors. In contrast to tamoxifen, the glyceollins had no estrogen-agonist effects on uterine morphology and partially antagonized the uterotropic effects of estrogen. Conclusions: These findings identify glyceollins as antiestrogenic agents that may be useful in the prevention or treatment of breast and ovarian carcinoma.

Idioma originalEnglish (US)
Páginas (desde-hasta)7159-7164
Número de páginas6
PublicaciónClinical Cancer Research
EstadoPublished - dic 1 2006
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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