TY - JOUR
T1 - Anticancer activity of limonoid from Khaya senegalensis
AU - Zhang, Huaping
AU - Wang, Xi
AU - Chen, Feng
AU - Androulakis, Xiao M.
AU - Wargovich, Michael J.
PY - 2007/8
Y1 - 2007/8
N2 - Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.
AB - Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.
KW - 1-O-acetylkhayanolide B
KW - 3α,7α-dideacetylkhivorin
KW - Antiproliferative activity
KW - Khaya senegalensis
KW - Limonoid
KW - Meliaceae
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U2 - 10.1002/ptr.2148
DO - 10.1002/ptr.2148
M3 - Article
C2 - 17450502
AN - SCOPUS:34547683549
SN - 0951-418X
VL - 21
SP - 731
EP - 734
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 8
ER -