Anthrax, toxins and vaccines: A 125-year journey targeting Bacillus anthracis

Jean Nicolas Tournier, Robert G. Ulrich, Anne Quesnel-Hellmann, Mansour Mohamadzadeh, Bradley G. Stiles

Resultado de la investigación: Review articlerevisión exhaustiva

44 Citas (Scopus)

Resumen

Bacillus anthracis is the causative agent of anthrax, a disease that plagues both humans and various animal species. Effective vaccines are available, but those approved for human use are crude culture supernatants that require multiple injections and a yearly boost. Many experts agree that it is now time for the next generation of human vaccines against anthrax. Accordingly, this review will succinctly focus upon: pathogenesis of B. anthracis, with particular emphasis upon the immune system; the pertinent biophysical nature of protective antigen, which includes how the protein toxin component affords protection as a vaccine target; alternative methods for improving protective antigen as an immunogen; and additional B. anthracis antigens that might further sustain protective titers in humans. In addition to a better understanding of the disease process elicited by B. anthracis, which will logically lead to better vaccines (and therapeutics), there also needs to be the same level of open-mindedness applied to the politics of anthrax.

Idioma originalEnglish (US)
Páginas (desde-hasta)219-236
Número de páginas18
PublicaciónExpert Review of Anti-Infective Therapy
Volumen7
N.º2
DOI
EstadoPublished - mar. 2009
Publicado de forma externa

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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