TY - JOUR
T1 - Anthrax SET protein
T2 - A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages
AU - Mujtaba, Shiraz
AU - Winer, Benjamin Y.
AU - Jaganathan, Anbalagan
AU - Patel, Jigneshkumar
AU - Sgobba, Miriam
AU - Schuch, Raymond
AU - Gupta, Yogesh K.
AU - Haider, Shozeb
AU - Wang, Rong
AU - Fischetti, Vincent A.
PY - 2013/8/9
Y1 - 2013/8/9
N2 - Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.
AB - Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.
UR - https://www.scopus.com/pages/publications/84881449055
UR - https://www.scopus.com/pages/publications/84881449055#tab=citedBy
U2 - 10.1074/jbc.M113.467696
DO - 10.1074/jbc.M113.467696
M3 - Article
C2 - 23720780
AN - SCOPUS:84881449055
SN - 0021-9258
VL - 288
SP - 23458
EP - 23472
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 32
ER -