TY - CHAP
T1 - Animal Models of Gynecological Cancers
AU - Venkata, Prabhakar Pitta
AU - Medina, Daisy
AU - Nirzhor, Saif S.R.
AU - Sittadjody, Sivanandane
AU - Ileng Kumaran, R.
AU - Ramachandran, Ilangovan
AU - Subbarayalu, Panneerdoss
N1 - Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2023.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Gynecological cancers develop in the reproductive organs of a woman. The common gynecological cancers are cervical, ovarian, uterine, vaginal, and vulvar cancers. Most of the gynecological cancers including the ovarian cancers undergo metastasis to distant organs, acquire resistance to cancer therapy, and relapse. There are no specific diagnostic biomarkers available to detect the early stages of gynecological cancers. The challenges to diagnose and treat gynecological cancers stem from the fact that these cancers are heterogeneous diseases and, therefore, need physiologically relevant animal model systems in order to develop strategies to discover targeted therapeutics. In this book chapter, the authors elaborate on mouse models that serve as helpful tools to understand the biology of gynecological cancers as well as the identification of biomarkers and novel therapeutics.
AB - Gynecological cancers develop in the reproductive organs of a woman. The common gynecological cancers are cervical, ovarian, uterine, vaginal, and vulvar cancers. Most of the gynecological cancers including the ovarian cancers undergo metastasis to distant organs, acquire resistance to cancer therapy, and relapse. There are no specific diagnostic biomarkers available to detect the early stages of gynecological cancers. The challenges to diagnose and treat gynecological cancers stem from the fact that these cancers are heterogeneous diseases and, therefore, need physiologically relevant animal model systems in order to develop strategies to discover targeted therapeutics. In this book chapter, the authors elaborate on mouse models that serve as helpful tools to understand the biology of gynecological cancers as well as the identification of biomarkers and novel therapeutics.
KW - Animal model
KW - Cancer
KW - Endometrial cancer
KW - Gynecological cancer
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=85160181932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85160181932&partnerID=8YFLogxK
U2 - 10.1007/978-981-19-3824-5_18
DO - 10.1007/978-981-19-3824-5_18
M3 - Chapter
AN - SCOPUS:85160181932
SN - 9789811938238
SP - 335
EP - 352
BT - Handbook of Animal Models and its Uses in Cancer Research
PB - Springer Nature
ER -