Angiopoietin-2, its soluble receptor Tie-2, and metabolic syndrome components in a population-based sample

Roberto Lorbeer, Sebastian E. Baumeister, Marcus Dörr, Matthias Nauck, Anne Grotevendt, Sabrina Schlesinger, Alexander Teumer, Henry Völzke, Hans Jörgen Grabe, Henri Wallaschofski, Ramachandran S. Vasan, Wolfgang Lieb

Producción científica: Articlerevisión exhaustiva

3 Citas (Scopus)

Resumen

Objective: Since angiopoietin-2 (Ang-2) levels strongly correlate with cardiovascular mortality and subclinical cardiovascular disease, it was hypothesized that levels of Ang-2 and its soluble receptor (sTie-2) were associated with the metabolic syndrome (MetS) and individual MetS components. Methods: Within the population-based Study of Health in Pomerania, two sets of analyses were performed. First, Ang-2 and sTie-2 were related to the prevalence of MetS and its components cross-sectionally (n = 3,205). Second, the association between baseline Ang-2 and sTie-2 and incident MetS or longitudinal changes in its components in 1,295 individuals was investigated. Results: High Ang-2 levels (90th percentile), compared with low Ang-2 levels (10th percentile), were positively associated with MetS (OR: 1.78) and with the following MetS criteria: increased triglycerides, lower HDL cholesterol, and higher non-fasting glucose. Furthermore, high sTie-2 levels (90th percentile), compared with low levels (10th percentile), were positively related to MetS (OR: 1.58) and most of its components. However, Ang-2 and sTie-2 levels were not associated with incident MetS or longitudinal change in components of MetS. Conclusions: Ang-2 and sTie-2 levels were cross-sectionally associated with MetS and several of its components. However, Ang-2 and sTie-2 levels were not associated with incident MetS or changes in individual MetS components during follow-up.

Idioma originalEnglish (US)
Páginas (desde-hasta)2038-2041
Número de páginas4
PublicaciónObesity
Volumen24
N.º10
DOI
EstadoPublished - oct 1 2016
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrinology
  • Nutrition and Dietetics
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism

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