Angiogenesis and anti-angiogenic therapy in myelofibrosis with myeloid metaplasia

Brijesh Arora, Ruben A. Mesa, Ayalew Tefferi

Resultado de la investigación: Review articlerevisión exhaustiva


Myelofibrosis with myeloid metaplasia (MMM) is a clonal stem cell disorder that is characterized by florid bone marrow stromal reaction including collagen fibrosis, osteosclerosis, and angiogenesis. Almost all patients with MMM display increased bone marrow microvessel density (MVD) and the extent is among the highest in hematological malignancies. This particular information has encouraged the therapeutic use of anti-angiogenic drugs in MMM. In the current review, we summarize the general concepts regarding angiogenesis, assessment of angiogenesis in hematological malignancies and then the current literature on angiogenesis and anti-angiogenic therapy in MMM.

Idioma originalEnglish (US)
Páginas (desde-hasta)2373-2386
Número de páginas14
PublicaciónLeukemia and Lymphoma
EstadoPublished - dic 2004
Publicado de forma externa

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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