@article{31802d50bb6545318585912c2833c178,
title = "An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians",
abstract = "Genetic factors influence the development of type II diabetes mellitus, but genetic loci for the most common forms of diabetes have not been identified. A genomic scan was conducted to identify loci linked to diabetes and body-mass index (BMI) in Pima Indians, a Native American population with a high prevalence of type II diabetes. Among 264 nuclear families containing 966 siblings, 516 autosomal markers with a median distance between adjacent markers of 6.4 cM were genotyped. Variance-components methods were used to test for linkage with an age-adjusted diabetes score and with BMI. In multipoint analyses, the strongest evidence for linkage with age-adjusted diabetes (LOD = 1.7) was on chromosome 11q, in the region that was also linked most strongly with BMI (LOD = 3.6). Bivariate linkage analyses strongly rejected both the null hypothesis of no linkage with either trait and the null hypothesis of no contribution of the locus to the covariation among the two traits. Sib-pair analyses suggest additional potential diabetes-susceptibility loci on chromosomes 1q and 7q.",
author = "Hanson, {Robert L.} and Ehm, {Margaret G.} and Pettitt, {David J.} and Michal Prochazka and Thompson, {D. Bruce} and David Timberlake and Tatiana Foroud and Sayuko Kobes and Leslie Baier and Burns, {Daniel K.} and Laura Almasy and John Blangero and Garvey, {W. Timothy} and Bennett, {Peter H.} and Knowler, {William C.}",
note = "Funding Information: This work was supported partly under the terms of a Collaborative Research and Development Agreement between Glaxo-Wellcome, Plc, and the National Institute of Diabetes and Digestive and Kidney Diseases. Some of the results of this paper were obtained with the program package SAGE, which is supported by U.S. Public Health Service Resource Grant 1 P41 RR03655 from the National Center for Research Resources. W.T.G. is supported partly by National Institutes of Health (NIH) grant DK-47461, and L.A. is supported partly by NIH grant GM-18897. The authors thank the members of the Gila River Indian Community who have participated in these studies. Particular thanks are due to Vickie Andre, Sonja Antone, Linda Phillips, and the rest of the Diabetes and Arthritis Epidemiology Section, for conducting clinical examinations; to Warren Apel, Rachel Janssen, Vicky Ossowski, Nancy Riebow, Jeff Sutherland, Pam Thuillez, and Tina Xi (all of Phoenix), for technical assistance; to Philip Picciotti (Phoenix), Hakan Sakul (Sequana Therapeutics), Tai-He Xia (Glaxo-Wellcome), and Robert C. Williams (Arizona State University), for assistance with data analysis; to Don Holt (Glaxo-Wellcome), for preparation of the genetic maps; to Derek Traughber, Gopi Gopalam, and Madhu Sethi (all of Glaxo-Wellcome), for technical assistance; and to Ray Grimaila, Quan Nguyen, and David Yarnall (all of Glaxo-Wellcome), for selecting and genotyping markers. Additional advice was provided by Rodney Norman, Eric Ravussin, and Richard Pratley (all of Phoenix), Michael Wagner (Glaxo-Wellcome), and Lon Cardon (Sequana Therapeutics). Special thanks are also due to Clifton Bogardus (Phoenix), for advice and encouragement, and to Jeffrey C. Long (National Institute on Alcohol Abuse and Alcoholism), for advice.",
year = "1998",
doi = "10.1086/302061",
language = "English (US)",
volume = "63",
pages = "1130--1138",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",
}