Amphotericin B lipid complex compared with amphotericin B in the treatment of cryptococcal meningitis in patients with AIDS

Patricia K. Sharkey, John R. Graybill, Edward S. Johnson, Stephen G. Hausrath, Richard B. Pollard, Antonia Kolokathis, Donna Mildvan, Patty Fan-Havard, Robert H.K. Eng, Thomas F. Patterson, John C. Pottage, Michael S. Simberkoff, Judith Wolf, Richard D. Meyer, Renu Gupta, Lily W. Lee, David S. Gordon

Producción científica: Articlerevisión exhaustiva

210 Citas (Scopus)

Resumen

The study objective was to obtain preliminary information regarding the safety and efficacy of amphotericin B (AraB) lipid complex (ABLC) in the treatment of AIDS-associated cryptococcal meningitis. Of 55 patients randomly assigned to 6 weeks of therapy with ABLC (1.2-5.0 mg/[kg-d], with ascending doses for three sequential cohorts) or Amb (0.7-1.2 mg/[kg-d]), 46 received ≥ 12 doses. Transfusion requirements, mean decreases in hemoglobin level, and mean increases in creatinine level were significantly greater with Arab than with ABLC. The total number of adverse events, infusion-related events, and occurrences of hypomagnesemia and hypokalemia associated with each form of therapy were similar. Among 21 recipients of ABLC at a dosage of 5 mg/kg (daily for 2 weeks and then thrice weekly for 4 weeks), symptoms and signs resolved for 18 (86%). Of those receiving ≥ 12 doses of ABLC, cultures converted to negative for 8 (42%), were undeterminable for 3 (16%), and remained positive for 8 (42%) despite resolution of symptoms. Although preliminary, these data suggest ABLC has significant activity in patients with AIDS-associated cryptococcal meningitis. Because this formulation has less hematologic and renal toxicity than does AraB, further evaluation of ABLC is warranted.

Idioma originalEnglish (US)
Páginas (desde-hasta)315-321
Número de páginas7
PublicaciónClinical Infectious Diseases
Volumen22
N.º2
DOI
EstadoPublished - feb 1996
Publicado de forma externa

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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