Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L. Burnett, Ivan Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Resultado de la investigación: Articlerevisión exhaustiva

12 Citas (Scopus)


The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

Idioma originalEnglish (US)
Páginas (desde-hasta)70S-84S
PublicaciónInternational journal of toxicology
EstadoPublished - may 1 2019
Publicado de forma externa

ASJC Scopus subject areas

  • Toxicology


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