Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization

Hyung Geun Moon, Seung jae Kim, Jong Jin Jeong, Seon Sook Han, Nizar N. Jarjour, Hyun Lee, Sherry L. Abboud-Werner, Sangwoon Chung, Hak Soo Choi, Viswanathan Natarajan, Steven J. Ackerman, John W. Christman, Gye Young Park

Resultado de la investigación: Articlerevisión exhaustiva

40 Citas (Scopus)


Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway and alveolar microenvironment is enriched with colony stimulating factor-1 (CSF1) in response to allergen exposure. In this study we found that AEC-derived CSF1 had a critical role in the production of allergen reactive-IgE production. Furthermore, spatiotemporally secreted CSF1 regulated the recruitment of alveolar dendritic cells (DCs) and enhanced the migration of conventional DC2s (cDC2s) to the draining lymph node in an interferon regulatory factor 4 (IRF4)-dependent manner. CSF1 selectively upregulated the expression of the chemokine receptor CCR7 on the CSF1R + cDC2, but not the cDC1, population in response to allergen stimuli. Our data describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper 2 (Th2) cell-mediated allergic lung inflammation. Airway epithelial cells are the first line of defense against foreign antigens and influence the microenvironment of the lung by secreting bioactive mediators. Moon and colleagues demonstrate that airway epithelial cells regulate dendritic cells for trafficking aeroallergen and subsequent development of adaptive immune responses.

Idioma originalEnglish (US)
Páginas (desde-hasta)275-287.e5
EstadoPublished - ago 21 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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