Agmatine: A novel endogenous vasodilator substance

Yuqi Gao, Bulent Gumusel, Gabor Koves, Anand Prasad, Qingzhong Hao, Albert Hyman, Howard Lippton

Resultado de la investigación: Articlerevisión exhaustiva

51 Citas (Scopus)

Resumen

The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.

Idioma originalEnglish (US)
Páginas (desde-hasta)PL83-PL86
PublicaciónLife Sciences
Volumen57
N.º8
DOI
EstadoPublished - jul. 14 1995
Publicado de forma externa

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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