Age-related morphology trends of cortical sulci

Peter Kochunov, Jean François Mangin, Thomas Coyle, Jack Lancaster, Paul Thompson, Dennis Rivière, Yann Cointepas, Jean Régis, Anita Schlosser, Don R. Royall, Karl Zilles, John Mazziotta, Arthur Toga, Peter T. Fox

Producción científica: Articlerevisión exhaustiva

175 Citas (Scopus)


The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).

Idioma originalEnglish (US)
Páginas (desde-hasta)210-220
Número de páginas11
PublicaciónHuman Brain Mapping
EstadoPublished - nov 2005

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Anatomy


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