TY - JOUR
T1 - Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection
AU - Gonzalez Aleman, Gabriela
AU - Vavougios, George D.
AU - Tartaglia, Carmela
AU - Uvais, Nalakath A.
AU - Guekht, Alla
AU - Hosseini, Akram A.
AU - Lo Re, Vincenzina
AU - Ferreccio, Catterina
AU - D'Avossa, Giovanni
AU - Zamponi, Hernan P.
AU - Figueredo Aguiar, Mariana
AU - Yecora, Agustin
AU - Ul Haq Katshu, Mohammad Zia
AU - Stavrou, Vasileios T.
AU - Boutlas, Stylianos
AU - Gourgoulianis, Konstantinos I.
AU - Botero, Camila
AU - González Insúa, Francisco
AU - Perez-Lloret, Santiago
AU - Zinchuk, Mikhail
AU - Gersamija, Anna
AU - Popova, Sofya
AU - Bryzgalova, Yulia
AU - Sviatskaya, Ekaterina
AU - Russelli, Giovanna
AU - Avorio, Federica
AU - Wang, Sophia
AU - Edison, Paul
AU - Niimi, Yoshiki
AU - Sohrabi, Hamid R.
AU - Mukaetova Ladinska, Elizabeta B.
AU - Neidre, Daria
AU - de Erausquin, Gabriel A.
N1 - Publisher Copyright:
Copyright © 2025 Gonzalez Aleman, Vavougios, Tartaglia, Uvais, Guekht, Hosseini, Lo Re, Ferreccio, D'Avossa, Zamponi, Figueredo Aguiar, Yecora, Ul Haq Katshu, Stavrou, Boutlas, Gourgoulianis, Botero, González Insúa, Perez-Lloret, Zinchuk, Gersamija, Popova, Bryzgalova, Sviatskaya, Russelli, Avorio, Wang, Edison, Niimi, Sohrabi, Mukaetova Ladinska, Neidre and de Erausquin.
PY - 2024
Y1 - 2024
N2 - Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin. The profile and severity of cognitive impairment varied by age, with mild attentional impairment observed in young and middle-aged adults, but memory, language, and executive function impairment in older adults. The risk of moderate to severe impairment doubled in older adults. Moderately severe or severe impairment was significantly associated with infection diagnoses (chi-square = 26.57, p ≤ 0.0001) and the severity of anosmia (chi-square = 31.81, p ≤ 0.0001). We found distinct age-related phenotypes of cognitive impairment in patients recovering from COVID-19. We identified the severity of acute illness and the presence of olfactory dysfunction as the primary predictors of dementia-like impairment in older adults.
AB - Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin. The profile and severity of cognitive impairment varied by age, with mild attentional impairment observed in young and middle-aged adults, but memory, language, and executive function impairment in older adults. The risk of moderate to severe impairment doubled in older adults. Moderately severe or severe impairment was significantly associated with infection diagnoses (chi-square = 26.57, p ≤ 0.0001) and the severity of anosmia (chi-square = 31.81, p ≤ 0.0001). We found distinct age-related phenotypes of cognitive impairment in patients recovering from COVID-19. We identified the severity of acute illness and the presence of olfactory dysfunction as the primary predictors of dementia-like impairment in older adults.
KW - COVID-19
KW - age-dependent
KW - cognitive decline
KW - international cohort
KW - long COVID
UR - https://www.scopus.com/pages/publications/85215527433
UR - https://www.scopus.com/pages/publications/85215527433#tab=citedBy
U2 - 10.3389/fnagi.2024.1432357
DO - 10.3389/fnagi.2024.1432357
M3 - Article
C2 - 39839305
AN - SCOPUS:85215527433
SN - 1663-4365
VL - 16
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 1432357
ER -