Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways

Lalgi Hima, Mantavya N. Patel, Thangamani Kannan, Shaili Gour, Uday P. Pratap, Hannah P. Priyanka, Ramasamy Vasantharekha, Srinivasan ThyagaRajan

Producción científica: Articlerevisión exhaustiva

5 Citas (Scopus)

Resumen

The aim of this study was to investigate the alterations in the neuroendocrine-immune functions by using human peripheral blood mononuclear cells (hPBMCs) from three age groups (young, middle-aged, and old) of men and women for the analyses of lymphocyte proliferation and cytokine production, expression of cell signaling molecules, nitric oxide (NO) production, and expression of p-tyrosine hydroxylase (TH). Serum was examined for levels of testosterone in men, 17-β-estradiol in women, and cortisol in both sexes. Lymphoproliferation, expression of p-ERK, p-CREB, p-Akt, and p-TH, and levels of serum sex steroid hormones declined with age in men and women. However, TNF-α production and serum cortisol level increased with age in men and women. mTOR expression was higher in older men while it was lower in older women. IFN-γ and IL-6 production and expression of p-TH and p-mTOR were differentially regulated in men and women. These results suggest that intracellular signaling mediators may be involved in the age-related alterations in the neuroendocrine-immune interactions in men and women.

Idioma originalEnglish (US)
Número de artículo577290
PublicaciónJournal of Neuroimmunology
Volumen345
DOI
EstadoPublished - ago 15 2020
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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