TY - JOUR
T1 - Adriamycin cardiotoxicity and proton nuclear magnetic resonance relaxation properties
AU - Thompson, Randall C.
AU - Canby, Robert C.
AU - Lojeski, Edwin W.
AU - Ratner, Adam V.
AU - Fallon, John T.
AU - Pohost, Gerald M.
N1 - Funding Information:
From the Cardiac Unit, Masaachueetta General Hospital; and the Division of Cardiovascuk Dii, University of Alabama at Birmingham. Supported in part by National Heart, Lung, and Blood Institute Grants HL 32817 and HL 17667; by Fellowship Grant 13-431-346 of the American Heart Aaeoeiation, Iksachueetta aSilk% and by fellowships of the Stanley J. Sarnoff Society of Research in Cardiovascular Science. F&e&d for public&ion April 7,1986; revision accepted Oct. 1’7, 1936. Reprint requests: Gerald M. Pohoet, M.D., Division of Cardiovascular IXmse, Univetsity of Alabema et Birmingham, Tineley Harrison Tower, Boom 311, Birmingham, AL 35294.
PY - 1987/6
Y1 - 1987/6
N2 - Present noninvasive techniques to detect Adriamycin (doxorubicin) cardiotoxicity rely on assessment of myocardial function rather than direct observation of change in tissue character. Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxation properties T1 and T2 are related to certain biophysical properties of tissue such as water, lipid, and macromolecular content and have considerable impact on the intensity observed in nuclear magnetic resonance images. In a model of chronic Adriamycin cardiotoxicity in rats, T1 values of excised hearts were elevated, relative to control, in rats with histologic evidence of chronic cardiotoxicity (651 msec vs 622 msec, p < 0.05) and more so in rats with gross evidence of toxicity or heart failure (668 msec, p<0.005). No significant change in T2 was observed. This T1 prolongation increases as disease worsens, whereas water concentration did not change significantly. The results suggest that predictable prolongation in T1 occurs in association with cardiotoxicity. In conclusion, proton nuclear magnetic resonance imaging methods could provide a new means for assessing Adriamycin cardiotoxicity.
AB - Present noninvasive techniques to detect Adriamycin (doxorubicin) cardiotoxicity rely on assessment of myocardial function rather than direct observation of change in tissue character. Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxation properties T1 and T2 are related to certain biophysical properties of tissue such as water, lipid, and macromolecular content and have considerable impact on the intensity observed in nuclear magnetic resonance images. In a model of chronic Adriamycin cardiotoxicity in rats, T1 values of excised hearts were elevated, relative to control, in rats with histologic evidence of chronic cardiotoxicity (651 msec vs 622 msec, p < 0.05) and more so in rats with gross evidence of toxicity or heart failure (668 msec, p<0.005). No significant change in T2 was observed. This T1 prolongation increases as disease worsens, whereas water concentration did not change significantly. The results suggest that predictable prolongation in T1 occurs in association with cardiotoxicity. In conclusion, proton nuclear magnetic resonance imaging methods could provide a new means for assessing Adriamycin cardiotoxicity.
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U2 - 10.1016/0002-8703(87)90660-0
DO - 10.1016/0002-8703(87)90660-0
M3 - Article
C2 - 3591613
AN - SCOPUS:0023273523
SN - 0002-8703
VL - 113
SP - 1444
EP - 1449
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -