TY - CHAP
T1 - Acute Ischemic Stroke Presentation, Natural History, and Treatment
AU - Bandela, Sujani
AU - Mozumder, Aaisha S.
AU - Birnbaum, Lee A.
N1 - Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Acute ischemic stroke presents with various neurological manifestations that necessitate different emergent care pathways. Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) for acute ischemic stroke are being utilized more widely as a result of public awareness and expansion of clinical services with tele-stroke. Large vessel occlusion (LVO) stroke is being treated more expeditiously due to prehospital stroke severity assessments that enable EMS bypass protocols and Thrombectomy-Capable Centers that minimize EMS bypass travel times. Although MT has proven efficacy, IVT remains an important treatment for LVO, especially in drip-and-ship models. In addition to acute therapies, this chapter highlights common stroke syndrome presentations and outcomes, landmark clinical trials, neuroimaging modalities, and future directions.
AB - Acute ischemic stroke presents with various neurological manifestations that necessitate different emergent care pathways. Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) for acute ischemic stroke are being utilized more widely as a result of public awareness and expansion of clinical services with tele-stroke. Large vessel occlusion (LVO) stroke is being treated more expeditiously due to prehospital stroke severity assessments that enable EMS bypass protocols and Thrombectomy-Capable Centers that minimize EMS bypass travel times. Although MT has proven efficacy, IVT remains an important treatment for LVO, especially in drip-and-ship models. In addition to acute therapies, this chapter highlights common stroke syndrome presentations and outcomes, landmark clinical trials, neuroimaging modalities, and future directions.
KW - Advanced neuroimaging
KW - Door-in-door-out
KW - Intravenous thrombolysis
KW - Large vessel occlusion
KW - Mechanical thrombectomy
KW - Prehospital stroke severity assessments
KW - Tenecteplase
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U2 - 10.1007/978-3-030-88196-2_10
DO - 10.1007/978-3-030-88196-2_10
M3 - Chapter
AN - SCOPUS:85152804770
SN - 9783030881955
SP - 201
EP - 213
BT - Introduction to Vascular Neurosurgery
PB - Springer International Publishing
ER -