TY - JOUR
T1 - Acute effects of methylphenidate on impulsivity and attentional behavior among adolescents comorbid for ADHD and conduct disorder
AU - Dougherty, Donald M.
AU - Olvera, Rene L.
AU - Acheson, Ashley
AU - Hill-Kapturczak, Nathalie
AU - Ryan, Stacy R
AU - Mathias, Charles W.
N1 - Publisher Copyright:
© 2016 The Foundation for Professionals in Services for Adolescents
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) and Conduct Disorder (CD) experience deficits in neuropsychological measures of attention, inhibition, and reward processes. Methylphenidate treatment for ADHD and CD has acute effects on these processes. Some of these same aspects of performance are separately described in the Behavioral Model of Impulsivity, which uses a modified approach to measurement. This study characterized the acute effects of methylphenidate attention, initiation, inhibition, and reward processes described in this model of impulsivity. Thirty-one adolescents from the United States of America with comorbid ADHD and CD completed measures of impulsivity (response initiation, response inhibition, and consequence) and attention following placebo, 20 mg, and 40 mg of a long-acting dose of methylphenidate. Methylphenidate effects on attentional performance was more robust than on any of the measures of impulsivity. Adolescent performance from this behavioral perspective is interpreted in the context of divergence from previous neuropsychological tests of acute methylphenidate effects.
AB - Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) and Conduct Disorder (CD) experience deficits in neuropsychological measures of attention, inhibition, and reward processes. Methylphenidate treatment for ADHD and CD has acute effects on these processes. Some of these same aspects of performance are separately described in the Behavioral Model of Impulsivity, which uses a modified approach to measurement. This study characterized the acute effects of methylphenidate attention, initiation, inhibition, and reward processes described in this model of impulsivity. Thirty-one adolescents from the United States of America with comorbid ADHD and CD completed measures of impulsivity (response initiation, response inhibition, and consequence) and attention following placebo, 20 mg, and 40 mg of a long-acting dose of methylphenidate. Methylphenidate effects on attentional performance was more robust than on any of the measures of impulsivity. Adolescent performance from this behavioral perspective is interpreted in the context of divergence from previous neuropsychological tests of acute methylphenidate effects.
KW - Adolescence
KW - Attention deficit hyperactivity disorder
KW - Conduct disorder
KW - Impulsive behavior
KW - MethylPhenidate
UR - http://www.scopus.com/inward/record.url?scp=84994032286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994032286&partnerID=8YFLogxK
U2 - 10.1016/j.adolescence.2016.10.013
DO - 10.1016/j.adolescence.2016.10.013
M3 - Article
C2 - 27816696
AN - SCOPUS:84994032286
SN - 0140-1971
VL - 53
SP - 222
EP - 230
JO - Journal of Adolescence
JF - Journal of Adolescence
ER -