Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

Gloria M. González; Rolando Tijerina; Laura K. Najvar; Rosie Bocanegra; Michael G. Rinaldi; David Loebenberg; John R. Graybill

doi:10.1128/AAC.47.4.1436-1438.2003

Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

Gloria M. González, Rolando Tijerina, Laura K. Najvar, Rosie Bocanegra, Michael G. Rinaldi, David Loebenberg, John R. Graybill

Resultado de la investigación: Article › revisión exhaustiva

44 Citas (Scopus)

Resumen

Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

Idioma original	English (US)
Páginas (desde-hasta)	1436-1438
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	47
N.º	4
DOI	https://doi.org/10.1128/AAC.47.4.1436-1438.2003
Estado	Published - abr 1 2003
Publicado de forma externa	Sí

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.47.4.1436-1438.2003

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abstract = "Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.",

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AU - Bocanegra, Rosie

AU - Rinaldi, Michael G.

AU - Loebenberg, David

AU - Graybill, John R.

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AB - Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

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Activity of posaconazole against Pseudallescheria boydii: In vitro and in vivo assays

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