Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

George E. Griffin, Kwanyee Leung, Thomas M. Folks, Steven Kunkel, Gary J. Nabel

Resultado de la investigación: Articlerevisión exhaustiva

438 Citas (Scopus)

Resumen

THE latent period of AIDS is influenced by factors which activate human immunodeficiency virus (HIV) replication in different cell types. Although monocytic cells may provide a reservoir for virus production in vivo1-8, their regulation of HIV transcription has not been defined. We now report that HIV gene expression in the monocyte lineage is regulated by NF-kB, the same transcription factor known to stimulate the HIV enhancer in activated T cells9; however, control of NF-kB and HIV in monocytes differs from that observed in T cells. NF-kB-binding activity appears during the transition from promonocyte to monocyte in U937 cells induced to differentiate in vitro and is present constitutively in mature monocytes and macrophages. In a chronically infected pro-monocytic cell, Ul, differentiation is associated with HIV-1 replication as well as NF-kB binding activity. These findings suggest that NF-kB binding activity is developmentally regulated in the monocyte lineage, and that it provides one signal for HIV activation in these cells.

Idioma originalEnglish (US)
Páginas (desde-hasta)70-73
Número de páginas4
PublicaciónNature
Volumen339
N.º6219
DOI
EstadoPublished - 1989
Publicado de forma externa

ASJC Scopus subject areas

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