Actions of melatonin in the reduction of oxidative stress: A review

R. J. Reiter, D. X. Tan, C. Osuna, E. Gitto

Producción científica: Review articlerevisión exhaustiva

1143 Citas (Scopus)


Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant. In terms of direct free radical scavenging, melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Additionally, melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. The following antioxidative enzymes are also stimulated by melatonin: superoxide dismutase, glutathione peroxidase and glutathione reductase. Melatonin has been widely used as a protective agent against a wide variety of processes and agents that damage tissues via free radical mechanisms. Copyright (C) 2000 National Science Council.

Idioma originalEnglish (US)
Páginas (desde-hasta)444-458
Número de páginas15
PublicaciónJournal of Biomedical Science
EstadoPublished - 2000

ASJC Scopus subject areas

  • Biochemistry, medical
  • Pharmacology (medical)
  • Molecular Biology
  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism
  • Cell Biology


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