Acetic acid, a potent agent of tumor progression in the multistage mouse skin model for chemical carcinogenesis

J. B. Rotstein; T. J. Slaga

doi:10.1016/0304-3835(88)90243-1

Acetic acid, a potent agent of tumor progression in the multistage mouse skin model for chemical carcinogenesis

J. B. Rotstein, T. J. Slaga

Resultado de la investigación: Article › revisión exhaustiva

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Resumen

Acetic acid, a very weak tumor promoter in the multistage mouse skin model for chemical carcinogenesis, was found to be very effective at enhancing cancer development, when applied during the progression phase of the model. Papilloma-bearing mice when repeatedly treated with acetic acid had a greater carcinoma incidence and a greater conversion of papillomas to carcinomas than vehicle treated mice. Selective cytotoxicity is discussed as a possible mechanism.

Idioma original	English (US)
Páginas (desde-hasta)	87-90
Número de páginas	4
Publicación	Cancer Letters
Volumen	42
N.º	1-2
DOI	https://doi.org/10.1016/0304-3835(88)90243-1
Estado	Published - 1988
Publicado de forma externa	Sí

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Acetic acid, a potent agent of tumor progression in the multistage mouse skin model for chemical carcinogenesis",

abstract = "Acetic acid, a very weak tumor promoter in the multistage mouse skin model for chemical carcinogenesis, was found to be very effective at enhancing cancer development, when applied during the progression phase of the model. Papilloma-bearing mice when repeatedly treated with acetic acid had a greater carcinoma incidence and a greater conversion of papillomas to carcinomas than vehicle treated mice. Selective cytotoxicity is discussed as a possible mechanism.",

keywords = "acetic acid, chemical carcinogenesis, mouse skin, tumor progression",

author = "Rotstein, {J. B.} and Slaga, {T. J.}",

note = "Funding Information: This study was supported by NC1 grant CA 43278-02 and NIH grant no. RR5511-25. The authors also thank Dr. Susan M. Fischer for her comments on the manuscript.",

year = "1988",

doi = "10.1016/0304-3835(88)90243-1",

language = "English (US)",

volume = "42",

pages = "87--90",

journal = "Cancer Letters",

issn = "0304-3835",

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TY - JOUR

T1 - Acetic acid, a potent agent of tumor progression in the multistage mouse skin model for chemical carcinogenesis

AU - Rotstein, J. B.

AU - Slaga, T. J.

N1 - Funding Information: This study was supported by NC1 grant CA 43278-02 and NIH grant no. RR5511-25. The authors also thank Dr. Susan M. Fischer for her comments on the manuscript.

PY - 1988

Y1 - 1988

N2 - Acetic acid, a very weak tumor promoter in the multistage mouse skin model for chemical carcinogenesis, was found to be very effective at enhancing cancer development, when applied during the progression phase of the model. Papilloma-bearing mice when repeatedly treated with acetic acid had a greater carcinoma incidence and a greater conversion of papillomas to carcinomas than vehicle treated mice. Selective cytotoxicity is discussed as a possible mechanism.

AB - Acetic acid, a very weak tumor promoter in the multistage mouse skin model for chemical carcinogenesis, was found to be very effective at enhancing cancer development, when applied during the progression phase of the model. Papilloma-bearing mice when repeatedly treated with acetic acid had a greater carcinoma incidence and a greater conversion of papillomas to carcinomas than vehicle treated mice. Selective cytotoxicity is discussed as a possible mechanism.

KW - acetic acid

KW - chemical carcinogenesis

KW - mouse skin

KW - tumor progression

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U2 - 10.1016/0304-3835(88)90243-1

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AN - SCOPUS:0023742917

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VL - 42

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EP - 90

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

Acetic acid, a potent agent of tumor progression in the multistage mouse skin model for chemical carcinogenesis

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