ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

Elizabeth M. Poole; Margaret A. Gates; Brigit A. High; Stephen J. Chanock; Daniel W. Cramer; Julie M. Cunningham; Brooke L. Fridley; Simon A. Gayther; Ellen L. Goode; Edwin S. Iversen; Jolanta Lissowska; Rachel T.Palmieri Weber; Paul D.P. Pharoah; Catherine M. Phelan; Susan J. Ramus; Joellen M. Schildkraut; Rebecca Sutphen; Ya Yu Tsai; Jonathan Tyrer; Robert A. Vierkant; Nicolas Wentzensen; Hannah P. Yang; Kathryn L. Terry; Shelley S. Tworoger

doi:10.1007/s10552-012-0059-y

ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

Elizabeth M. Poole, Margaret A. Gates, Brigit A. High, Stephen J. Chanock, Daniel W. Cramer, Julie M. Cunningham, Brooke L. Fridley, Simon A. Gayther, Ellen L. Goode, Edwin S. Iversen, Jolanta Lissowska, Rachel T.Palmieri Weber, Paul D.P. Pharoah, Catherine M. Phelan, Susan J. Ramus, Joellen M. Schildkraut, Rebecca Sutphen, Ya Yu Tsai, Jonathan Tyrer, Robert A. VierkantNicolas Wentzensen, Hannah P. Yang, Kathryn L. Terry, Shelley S. Tworoger

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Resumen

Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

Idioma original	English (US)
Páginas (desde-hasta)	1805-1810
Número de páginas	6
Publicación	Cancer Causes and Control
Volumen	23
N.º	11
DOI	https://doi.org/10.1007/s10552-012-0059-y
Estado	Published - nov 2012
Publicado de forma externa	Sí

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10552-012-0059-y

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Poole, E. M., Gates, M. A., High, B. A., Chanock, S. J., Cramer, D. W., Cunningham, J. M., Fridley, B. L., Gayther, S. A., Goode, E. L., Iversen, E. S., Lissowska, J., Weber, R. T. P., Pharoah, P. D. P., Phelan, C. M., Ramus, S. J., Schildkraut, J. M., Sutphen, R., Tsai, Y. Y., Tyrer, J., ... Tworoger, S. S. (2012). ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. Cancer Causes and Control, 23(11), 1805-1810. https://doi.org/10.1007/s10552-012-0059-y

Poole, EM, Gates, MA, High, BA, Chanock, SJ, Cramer, DW, Cunningham, JM, Fridley, BL, Gayther, SA, Goode, EL, Iversen, ES, Lissowska, J, Weber, RTP, Pharoah, PDP, Phelan, CM, Ramus, SJ, Schildkraut, JM, Sutphen, R, Tsai, YY, Tyrer, J, Vierkant, RA, Wentzensen, N, Yang, HP, Terry, KL & Tworoger, SS 2012, 'ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium', Cancer Causes and Control, vol. 23, n.º 11, pp. 1805-1810. https://doi.org/10.1007/s10552-012-0059-y

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title = "ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium",

abstract = "Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.",

keywords = "ABO blood group, Genetic epidemiology, Ovarian cancer, Ovarian Cancer Association Consortium (OCAC)",

author = "Poole, {Elizabeth M.} and Gates, {Margaret A.} and High, {Brigit A.} and Chanock, {Stephen J.} and Cramer, {Daniel W.} and Cunningham, {Julie M.} and Fridley, {Brooke L.} and Gayther, {Simon A.} and Goode, {Ellen L.} and Iversen, {Edwin S.} and Jolanta Lissowska and Weber, {Rachel T.Palmieri} and Pharoah, {Paul D.P.} and Phelan, {Catherine M.} and Ramus, {Susan J.} and Schildkraut, {Joellen M.} and Rebecca Sutphen and Tsai, {Ya Yu} and Jonathan Tyrer and Vierkant, {Robert A.} and Nicolas Wentzensen and Yang, {Hannah P.} and Terry, {Kathryn L.} and Tworoger, {Shelley S.}",

year = "2012",

month = nov,

doi = "10.1007/s10552-012-0059-y",

language = "English (US)",

volume = "23",

pages = "1805--1810",

journal = "Cancer Causes and Control",

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number = "11",

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T1 - ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

AU - Poole, Elizabeth M.

AU - Gates, Margaret A.

AU - High, Brigit A.

AU - Chanock, Stephen J.

AU - Cramer, Daniel W.

AU - Cunningham, Julie M.

AU - Fridley, Brooke L.

AU - Gayther, Simon A.

AU - Goode, Ellen L.

AU - Iversen, Edwin S.

AU - Lissowska, Jolanta

AU - Weber, Rachel T.Palmieri

AU - Pharoah, Paul D.P.

AU - Phelan, Catherine M.

AU - Ramus, Susan J.

AU - Schildkraut, Joellen M.

AU - Sutphen, Rebecca

AU - Tsai, Ya Yu

AU - Tyrer, Jonathan

AU - Vierkant, Robert A.

AU - Wentzensen, Nicolas

AU - Yang, Hannah P.

AU - Terry, Kathryn L.

AU - Tworoger, Shelley S.

PY - 2012/11

Y1 - 2012/11

N2 - Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

AB - Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

KW - ABO blood group

KW - Genetic epidemiology

KW - Ovarian cancer

KW - Ovarian Cancer Association Consortium (OCAC)

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M3 - Article

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SN - 0957-5243

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EP - 1810

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 11

ER -

ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

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