Abnormalities in the enamel in Bmp2-deficient mice

Junsheng Feng, Guobin Yang, Guohua Yuan, Jelica Gluhak-Heinrich, Wuchen Yang, Lynn Wang, Zhi Chen, Jennifer Schulze McDaniel, Kevin J. Donly, Stephen E. Harris, Mary MacDougall, Shuo Chen

Producción científica: Articlerevisión exhaustiva

36 Citas (Scopus)


Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2 flox/flox mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation.

Idioma originalEnglish (US)
Páginas (desde-hasta)216-221
Número de páginas6
PublicaciónCells Tissues Organs
EstadoPublished - ago 2011

ASJC Scopus subject areas

  • Anatomy
  • Histology


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