@article{016c86e0537c4569b3cf5c1022ec5199,
title = "A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development",
abstract = "Lawrenson et al. profile gene expression and active chromatin in ∼200 ovarian and fallopian epithelial isolates and implement machine learning to demonstrate that most high-grade serous ovarian cancers (HGSOCs) derive from fallopian tube epithelial cells, but a subset may originate from ovarian epithelia. SOX18 induces mesenchymal features to drive early neoplasia in fallopian tube precursors.",
keywords = "RNA-seq, SOX18, dual origins, fallopian tube secretory epithelial cell, high-grade serous ovarian cancer, machine learning, one-class logistic regression models, ovarian surface epithelial cell, single-cell RNA-seq, super enhancers, transcription factors",
author = "Kate Lawrenson and Fonseca, \{Marcos A.S.\} and Liu, \{Annie Y.\} and \{Segato Dezem\}, Felipe and Lee, \{Janet M.\} and Xianzhi Lin and Corona, \{Rosario I.\} and Forough Abbasi and Vavra, \{Kevin C.\} and Dinh, \{Huy Q.\} and Gill, \{Navjot Kaur\} and Seo, \{Ji Heui\} and Simon Coetzee and Lin, \{Yvonne G.\} and Tanja Pejovic and Paulette Mhawech-Fauceglia and Rowat, \{Amy C.\} and Ronny Drapkin and Karlan, \{Beth Y.\} and Hazelett, \{Dennis J.\} and Freedman, \{Matthew L.\} and Gayther, \{Simon A.\} and Houtan Noushmehr",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = dec,
day = "10",
doi = "10.1016/j.celrep.2019.10.122",
language = "English (US)",
volume = "29",
pages = "3726--3735.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}