TY - JOUR
T1 - A Simple and Reliable Method to Assess Heart Viability After Hypothermic Procurement
AU - Ferrera, R.
AU - Bopassa, J. C.
AU - Rodriguez, C.
AU - Baverel, G.
AU - Ovize, M.
PY - 2006/9
Y1 - 2006/9
N2 - Hearts from brain dead pigs (n = 18) were submitted to 0 (group I), 10 (group II), or 20 (group III) minutes of in situ warm ischemia (animal exsanguination). After harvesting, cold cardioplegia solution was perfused in retrograde fashion and initial coronary flow (ICF) measured. After left ventricular energetic indices were measured using NMR spectroscopy, the hearts were transplanted orthotopically. Follow-up was performed over 120 minutes after cardiopulmonary bypass. We observed a progressive decrease in ICF with increased warm ischemia times: 50 ± 3.4 mL/min per 100 g of tissue in the group I, 36 ± 7 and 30 ± 3.5 in groups II and III, respectively (P < .05 and P < .01 versus group I). The ICF strongly correlated with the energetic index (r = 0.76, P < .001) and with posttransplant function of the transplanted heart. These data showed that measurement of initial coronary flow after cardioplegia was a reliable test to evaluate cardiac graft viability before transplantation.
AB - Hearts from brain dead pigs (n = 18) were submitted to 0 (group I), 10 (group II), or 20 (group III) minutes of in situ warm ischemia (animal exsanguination). After harvesting, cold cardioplegia solution was perfused in retrograde fashion and initial coronary flow (ICF) measured. After left ventricular energetic indices were measured using NMR spectroscopy, the hearts were transplanted orthotopically. Follow-up was performed over 120 minutes after cardiopulmonary bypass. We observed a progressive decrease in ICF with increased warm ischemia times: 50 ± 3.4 mL/min per 100 g of tissue in the group I, 36 ± 7 and 30 ± 3.5 in groups II and III, respectively (P < .05 and P < .01 versus group I). The ICF strongly correlated with the energetic index (r = 0.76, P < .001) and with posttransplant function of the transplanted heart. These data showed that measurement of initial coronary flow after cardioplegia was a reliable test to evaluate cardiac graft viability before transplantation.
UR - http://www.scopus.com/inward/record.url?scp=33846113318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846113318&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2006.06.124
DO - 10.1016/j.transproceed.2006.06.124
M3 - Article
C2 - 16980065
AN - SCOPUS:33846113318
SN - 0041-1345
VL - 38
SP - 2283
EP - 2284
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 7
ER -