A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis

Ling Lai, Miao Wang, Ola J. Martin, Teresa C. Leone, Rick B. Vega, Xianlin Han, Daniel P. Kelly

Resultado de la investigación: Articlerevisión exhaustiva

69 Citas (Scopus)

Resumen

Background: Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) γ and γ are transcriptional regulators of mitochondrial metabolism. Results: Loss of PGC-1 coactivators in mouse heart causes a defect in phospholipid biosynthesis resulting in mitochondrial ultrastructural abnormalities. Conclusion: PGC-1 coactivators coordinately regulate mitochondrial metabolism and structure. Significance: The mitochondrial phenotype of PGC-1-deficient mice resembles that of humans with genetic defects in mitochondrial phospholipid biosynthesis (Barth syndrome).

Idioma originalEnglish (US)
Páginas (desde-hasta)2250-2259
Número de páginas10
PublicaciónJournal of Biological Chemistry
Volumen289
N.º4
DOI
EstadoPublished - ene. 24 2014
Publicado de forma externa

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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