A random signal model for cDNA microarrays

Y. Balagurunathan; E. R. Dougherty; Y. Chen; M. L. Bitter; J. M. Trent

doi:10.1117/12.427985

A random signal model for cDNA microarrays

Y. Balagurunathan, E. R. Dougherty, Y. Chen, M. L. Bitter, J. M. Trent

Producción científica: Article › revisión exhaustiva

Resumen

The images resulting from cDNA microarrays are highly random. There are many aspects to this randomness, including spot size, shape, intensity, uniformity, and circularity, as well as both foreground and background noise. This paper presents a random model for the generation of microarray images. The model is complicated and contains over twenty parameters. It can be used to test microarray imaging algorithms and to simulate the effects of various dependencies within the image formation process.

Idioma original	English (US)
Páginas (desde-hasta)	163-170
Número de páginas	8
Publicación	Proceedings of SPIE-The International Society for Optical Engineering
Volumen	4266
DOI	https://doi.org/10.1117/12.427985
Estado	Published - 2001
Publicado de forma externa	Sí

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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KW - Simulated cDNA microarray

KW - cDNA spot model

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A random signal model for cDNA microarrays

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