TY - JOUR
T1 - A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
AU - Brandhorst, Sebastian
AU - Choi, In Young
AU - Wei, Min
AU - Cheng, Chia Wei
AU - Sedrakyan, Sargis
AU - Navarrete, Gerardo
AU - Dubeau, Louis
AU - Yap, Li Peng
AU - Park, Ryan
AU - Vinciguerra, Manlio
AU - Di Biase, Stefano
AU - Mirzaei, Hamed
AU - Mirisola, Mario G.
AU - Childress, Patra
AU - Ji, Lingyun
AU - Groshen, Susan
AU - Penna, Fabio
AU - Odetti, Patrizio
AU - Perin, Laura
AU - Conti, Peter S.
AU - Ikeno, Yuji
AU - Kennedy, Brian K.
AU - Cohen, Pinchas
AU - Morgan, Todd E.
AU - Dorff, Tanya B.
AU - Longo, Valter D.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/7/7
Y1 - 2015/7/7
N2 - Summary Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, 4 days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems, an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles started at middle age extended longevity, lowered visceral fat, reduced cancer incidence and skin lesions, rejuvenated the immune system, and retarded bone mineral density loss. In old mice, FMD cycles promoted hippocampal neurogenesis, lowered IGF-1 levels and PKA activity, elevated NeuroD1, and improved cognitive performance. In a pilot clinical trial, three FMD cycles decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.
AB - Summary Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, 4 days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems, an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles started at middle age extended longevity, lowered visceral fat, reduced cancer incidence and skin lesions, rejuvenated the immune system, and retarded bone mineral density loss. In old mice, FMD cycles promoted hippocampal neurogenesis, lowered IGF-1 levels and PKA activity, elevated NeuroD1, and improved cognitive performance. In a pilot clinical trial, three FMD cycles decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.
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U2 - 10.1016/j.cmet.2015.05.012
DO - 10.1016/j.cmet.2015.05.012
M3 - Article
C2 - 26094889
AN - SCOPUS:84937392878
SN - 1550-4131
VL - 22
SP - 86
EP - 99
JO - Cell Metabolism
JF - Cell Metabolism
IS - 1
ER -