A multifaceted role for MOF histone modifying factor in genome maintenance

Kalpana Mujoo, Clayton R. Hunt, Nobuo Horikoshi, Tej K. Pandita

Producción científica: Review articlerevisión exhaustiva

10 Citas (Scopus)

Resumen

MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome. In humans, however, the ortholog of Drosophila MOF has been shown to interact with a range of proteins that extend its potential significance well beyond transcription. For example, recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways. Thus, directly or indirectly, MOF may be involved in a wide range of cellular functions. This review will focus on the contribution of MOF to cellular DNA repair and new results that are beginning to examine the in vivo physiological role of MOF.

Idioma originalEnglish (US)
Páginas (desde-hasta)177-180
Número de páginas4
PublicaciónMechanisms of Ageing and Development
Volumen161
DOI
EstadoPublished - ene 1 2017
Publicado de forma externa

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Huella

Profundice en los temas de investigación de 'A multifaceted role for MOF histone modifying factor in genome maintenance'. En conjunto forman una huella única.

Citar esto