A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection

Background: Radiotherapy protection depends on a selective protection of normal tissues but not tumors. Results: We demonstrate that low doses of arsenic induce a p53/HIF-1-dependent metabolic reprogramming specific to normal cells, resulting in increased resistance to radiation toxicity. Conclusion: p53-mediated metabolic reprogramming can be explored for normal tissue protection. Significance: The use of low-dose arsenic for selective protection of normal tissues may have important therapeutic implications.