A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai; Xin Chen; Andreas Linkermann; Xuejun Jiang; Rui Kang; Valerian E. Kagan; Hülya Bayir; Wan Seok Yang; Ana J. Garcia-Saez; Maria S. Ioannou; Tobias Janowitz; Qitao Ran; Wei Gu; Boyi Gan; Dmitri V. Krysko; Xiaofeng Zhu; Jiayi Wang; Stefan Krautwald; Shinya Toyokuni; Yangchun Xie; Florian R. Greten; Qing Yi; Joel Schick; Jiao Liu; Dmitry I. Gabrilovich; Jinbao Liu; Herbert J. Zeh; Donna D. Zhang; Minghua Yang; Juan Iovanna; Manfred Kopf; Timon E. Adolph; Jen Tsan Chi; Changfeng Li; Hidenori Ichijo; Michael Karin; Vijay G. Sankaran; Weiping Zou; Lorenzo Galluzzi; Ashley I. Bush; Binghui Li; Gerry Melino; Eric H. Baehrecke; Michael T. Lotze; Daniel J. Klionsky; Brent R. Stockwell; Guido Kroemer; Daolin Tang

doi:10.1038/s41556-024-01360-8

A guideline on the molecular ecosystem regulating ferroptosis

Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana J. Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun XieFlorian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D. Zhang, Minghua Yang, Juan Iovanna, Manfred Kopf, Timon E. Adolph, Jen Tsan Chi, Changfeng Li, Hidenori Ichijo, Michael Karin, Vijay G. Sankaran, Weiping Zou, Lorenzo Galluzzi, Ashley I. Bush, Binghui Li, Gerry Melino, Eric H. Baehrecke, Michael T. Lotze, Daniel J. Klionsky, Brent R. Stockwell, Guido Kroemer, Daolin Tang

Producción científica: Review article › revisión exhaustiva

74 Citas (Scopus)

Resumen

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Idioma original	English (US)
Páginas (desde-hasta)	1447-1457
Número de páginas	11
Publicación	Nature Cell Biology
Volumen	26
N.º	9
DOI	https://doi.org/10.1038/s41556-024-01360-8
Estado	Published - sept 2024
Publicado de forma externa	Sí

ASJC Scopus subject areas

Cell Biology

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10.1038/s41556-024-01360-8

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Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., Bayir, H., Yang, W. S., Garcia-Saez, A. J., Ioannou, M. S., Janowitz, T., Ran, Q., Gu, W., Gan, B., Krysko, D. V., Zhu, X., Wang, J., Krautwald, S., Toyokuni, S., ... Tang, D. (2024). A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology, 26(9), 1447-1457. https://doi.org/10.1038/s41556-024-01360-8

Dai, E, Chen, X, Linkermann, A, Jiang, X, Kang, R, Kagan, VE, Bayir, H, Yang, WS, Garcia-Saez, AJ, Ioannou, MS, Janowitz, T, Ran, Q, Gu, W, Gan, B, Krysko, DV, Zhu, X, Wang, J, Krautwald, S, Toyokuni, S, Xie, Y, Greten, FR, Yi, Q, Schick, J, Liu, J, Gabrilovich, DI, Liu, J, Zeh, HJ, Zhang, DD, Yang, M, Iovanna, J, Kopf, M, Adolph, TE, Chi, JT, Li, C, Ichijo, H, Karin, M, Sankaran, VG, Zou, W, Galluzzi, L, Bush, AI, Li, B, Melino, G, Baehrecke, EH, Lotze, MT, Klionsky, DJ, Stockwell, BR, Kroemer, G & Tang, D 2024, 'A guideline on the molecular ecosystem regulating ferroptosis', Nature Cell Biology, vol. 26, n.º 9, pp. 1447-1457. https://doi.org/10.1038/s41556-024-01360-8

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abstract = "Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.",

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AU - Xie, Yangchun

AU - Greten, Florian R.

AU - Yi, Qing

AU - Schick, Joel

AU - Liu, Jiao

AU - Gabrilovich, Dmitry I.

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AU - Kopf, Manfred

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A guideline on the molecular ecosystem regulating ferroptosis

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