A comprehensive review of protein kinase inhibitors for cancer therapy

Radhamani Kannaiyan, Daruka Mahadevan

Producción científica: Review articlerevisión exhaustiva

178 Citas (Scopus)

Resumen

Introduction: Protein kinases are involved in various cellular functions. About 2% of the human genome encodes for protein kinases. Dysregulation of protein kinases is implicated in various processes of carcinogenesis. The advent of protein kinase inhibitors in cancer therapy has led to a paradigm shift in cancer therapy. Several protein kinase inhibitors have been approved by FDA in the last few decades. Areas covered: This article provides a review of the FDA approved protein kinase inhibitors as of December 2017 for the well-known oncogenic protein kinases. A list of FDA approved protein kinase inhibitors and their FDA approved clinical indications were cataloged. The role of the respective oncogenic protein kinases in carcinogenesis and cancer progression and the relevant landmark clinical trials of respective protein kinase inhibitors leading up to the FDA approval were PubMed searched and discussed. Expert commentary: Further understanding of the molecular origin of various cancers would help identify new targets. Use of biomarker profiling might select the patient population that would benefit better from kinase inhibitors. Clinical trials should be designed to identify the appropriate sequence of the available kinase inhibitors. It would prove to be useful to test these drugs in the adjuvant setting.

Idioma originalEnglish (US)
Páginas (desde-hasta)1249-1270
Número de páginas22
PublicaciónExpert Review of Anticancer Therapy
Volumen18
N.º12
DOI
EstadoPublished - dic 2 2018
Publicado de forma externa

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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