A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

Producción científica: Review articlerevisión exhaustiva

147 Citas (Scopus)

Resumen

There are currently no disease-modifying therapies for the treatment of tauopathies, a group of progressive neurodegenerative disorders that are pathologically defined by the presence of tau protein aggregates in the brain. Current challenges for the treatment of tauopathies include the inability to diagnose early and to confidently discriminate between distinct tauopathies in patients, alongside an incomplete understanding of the cellular mechanisms involved in pathogenic tau-induced neuronal death and dysfunction. In this review, we describe current diagnostic and therapeutic strategies, known drivers of pathogenic tau formation, recent contributions to our current mechanistic understanding of how pathogenic tau induces neuronal death, and potential diagnostic and therapeutic approaches.

Idioma originalEnglish (US)
Páginas (desde-hasta)637-648
Número de páginas12
PublicaciónTrends in Pharmacological Sciences
Volumen38
N.º7
DOI
EstadoPublished - jul 2017

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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