δ scores predict mild cognitive impairment and Alzheimer's disease conversions from nondemented states

Introduction We tested the latent variable “δ” (for “dementia”)s ability to predict conversion to “mild cognitive impairment” (MCI) and Alzheimer's disease (AD). Methods An ethnicity equivalent d homolog (“dEQ”) was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. “Normal Controls” (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)]. Results 22.0% (n = 281) of NC converted to “MCI” or “AD”. 17.3%(n = 106) of MCI converted to “AD.” Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52%. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. Discussion Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.