β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Elaine D. Por; Sonya M. Bierbower; Kelly A. Berg; Ruben Gomez; Armen N. Akopian; William C. Wetsel; Nathaniel A. Jeske

doi:10.1074/jbc.M112.391847

β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Elaine D. Por, Sonya M. Bierbower, Kelly A. Berg, Ruben Gomez, Armen N. Akopian, William C. Wetsel, Nathaniel A. Jeske

Producción científica: Article › revisión exhaustiva

46 Citas (Scopus)

Resumen

Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

Idioma original	English (US)
Páginas (desde-hasta)	37552-37563
Número de páginas	12
Publicación	Journal of Biological Chemistry
Volumen	287
N.º	44
DOI	https://doi.org/10.1074/jbc.M112.391847
Estado	Published - oct 26 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.391847

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title = "β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel",

abstract = "Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.",

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AU - Bierbower, Sonya M.

AU - Berg, Kelly A.

AU - Gomez, Ruben

AU - Akopian, Armen N.

AU - Wetsel, William C.

AU - Jeske, Nathaniel A.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

AB - Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

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β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

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