β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel

Elaine D. Por, Sonya M. Bierbower, Kelly A. Berg, Ruben Gomez, Armen N. Akopian, William C. Wetsel, Nathaniel A. Jeske

Producción científica: Articlerevisión exhaustiva

43 Citas (Scopus)

Resumen

Background: The TRPV1 receptor is an ionotropic receptor implicated in a variety of pain and inflammatory disorders. Results: β-Arrestin-2 scaffolds phosphodiesterase PDE4D5 to TRPV1 to regulate receptor phosphorylation and activity. Conclusion: β-Arrestin-2 functions as a scaffold protein to mediate TRPV1 desensitization in multiple cell models. Significance: Our findings presented herein provide compelling support for the contribution of β-arrestins as scaffolding proteins in the regulation of ligand-gated ion channels.

Idioma originalEnglish (US)
Páginas (desde-hasta)37552-37563
Número de páginas12
PublicaciónJournal of Biological Chemistry
Volumen287
N.º44
DOI
EstadoPublished - oct 26 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology

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