Astrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis

  • Jyoti Srivastava (Contributor)
  • Ayesha Siddiq (Contributor)
  • Rachel Gredler (Contributor)
  • Devaraja Rajasekaran (Contributor)
  • D. Garcia (Contributor)
  • Zhao Lai (Contributor)
  • Yidong Chen (Contributor)
  • Uthra Balaji (Contributor)
  • Devanand Sarkar (Contributor)

Dataset

Description

Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve adult mice (3 mice/group). Total RNA was extrancted and subjected to RNA-Seq.
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