Abstract
Zygomycetes are ubiquitous fungi that can cause invasive disease associated with high mortality. We report 10 solid organ transplant recipients with zygomycosis (incidence 2 per 1000) and reviewed 106 cases in the English-language literature. These included renal (n = 73), heart (n = 16), lung (n = 4), heart/lung (n = 2), liver (n = 19) and kidney/pancreas (n = 2) transplant recipients. All patients were receiving immunosuppression and the vast majority steroids. The clinical presentation included rhino-sino-orbital (n = 20), rhinocerebral (n = 16), pulmonary (n = 28), gastrointestinal (n = 13), cutaneous (n = 18), renal (n = 6) and disseminated disease (n = 15). Most frequently isolated genera were Rhizopus (73%) followed by Mucor (13%). The overall mortality was 49%. While rhino-sino-orbital disease had the best prognosis, rhinocerebral disease had high mortality (93%) comparable to disseminated disease. A favorable outcome was associated with limited, surgically accessible disease and early surgical intervention along with amphotericin B administration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2365-2374 |
| Number of pages | 10 |
| Journal | American Journal of Transplantation |
| Volume | 6 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2006 |
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Keywords
- Mould
- Mucorales
- Solid organ transplantation
- Zygomycosis
ASJC Scopus subject areas
- Immunology
Cite this
Zygomycosis in solid organ transplant recipients in a tertiary transplant center and review of the literature. / Almyroudis, N. G.; Sutton, D. A.; Linden, P.; Rinaldi, M. G.; Fung, J.; Kusne, S.
In: American Journal of Transplantation, Vol. 6, No. 10, 10.2006, p. 2365-2374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Zygomycosis in solid organ transplant recipients in a tertiary transplant center and review of the literature
AU - Almyroudis, N. G.
AU - Sutton, D. A.
AU - Linden, P.
AU - Rinaldi, M. G.
AU - Fung, J.
AU - Kusne, S.
PY - 2006/10
Y1 - 2006/10
N2 - Zygomycetes are ubiquitous fungi that can cause invasive disease associated with high mortality. We report 10 solid organ transplant recipients with zygomycosis (incidence 2 per 1000) and reviewed 106 cases in the English-language literature. These included renal (n = 73), heart (n = 16), lung (n = 4), heart/lung (n = 2), liver (n = 19) and kidney/pancreas (n = 2) transplant recipients. All patients were receiving immunosuppression and the vast majority steroids. The clinical presentation included rhino-sino-orbital (n = 20), rhinocerebral (n = 16), pulmonary (n = 28), gastrointestinal (n = 13), cutaneous (n = 18), renal (n = 6) and disseminated disease (n = 15). Most frequently isolated genera were Rhizopus (73%) followed by Mucor (13%). The overall mortality was 49%. While rhino-sino-orbital disease had the best prognosis, rhinocerebral disease had high mortality (93%) comparable to disseminated disease. A favorable outcome was associated with limited, surgically accessible disease and early surgical intervention along with amphotericin B administration.
AB - Zygomycetes are ubiquitous fungi that can cause invasive disease associated with high mortality. We report 10 solid organ transplant recipients with zygomycosis (incidence 2 per 1000) and reviewed 106 cases in the English-language literature. These included renal (n = 73), heart (n = 16), lung (n = 4), heart/lung (n = 2), liver (n = 19) and kidney/pancreas (n = 2) transplant recipients. All patients were receiving immunosuppression and the vast majority steroids. The clinical presentation included rhino-sino-orbital (n = 20), rhinocerebral (n = 16), pulmonary (n = 28), gastrointestinal (n = 13), cutaneous (n = 18), renal (n = 6) and disseminated disease (n = 15). Most frequently isolated genera were Rhizopus (73%) followed by Mucor (13%). The overall mortality was 49%. While rhino-sino-orbital disease had the best prognosis, rhinocerebral disease had high mortality (93%) comparable to disseminated disease. A favorable outcome was associated with limited, surgically accessible disease and early surgical intervention along with amphotericin B administration.
KW - Mould
KW - Mucorales
KW - Solid organ transplantation
KW - Zygomycosis
UR - http://www.scopus.com/inward/record.url?scp=33748496281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748496281&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2006.01496.x
DO - 10.1111/j.1600-6143.2006.01496.x
M3 - Article
C2 - 16925570
AN - SCOPUS:33748496281
VL - 6
SP - 2365
EP - 2374
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 10
ER -