TY - JOUR
T1 - Zika virus challenges for neuropsychiatry
AU - Simões e Silva, Ana Cristina
AU - Moreira, Janaina Matos
AU - Romanelli, Roberta Maia Castro
AU - Teixeira, Antonio Lucio
N1 - Publisher Copyright:
© 2016 Simoes e Silva et al.
PY - 2016/7/14
Y1 - 2016/7/14
N2 - Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain-Barre syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations.
AB - Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain-Barre syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations.
KW - Guillain-Barré syndrome
KW - Microcephaly
KW - Neurodevelopmental disorders
KW - Zika virus
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U2 - 10.2147/NDT.S113037
DO - 10.2147/NDT.S113037
M3 - Review article
AN - SCOPUS:84978485749
SN - 1176-6328
VL - 12
SP - 1747
EP - 1760
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
ER -