@article{7b979a4d149147e7bcdf82c97a992834,
title = "Zebrafish Tumor Graft Transplantation to Grow Tumors in Vivo That Engraft Poorly as Single Cell Suspensions",
abstract = "Angiosarcoma is a clinically aggressive tumor with a high rate of mortality. It can arise in vascular or lymphatic tissues, involve any part of the body, and aggressively spread locally or metastasize. Angiosarcomas spontaneously develop in the tp53 deleted (tp53del/del) zebrafish mutant. However, established protocols for tumor dissection and transplantation of single cell suspensions of angiosarcoma tumors result in inferior implantation rates. To resolve these complications, we developed a new tumor grafting technique for engraftment of angiosarcoma and similar tumors in zebrafish, which maintains the tumor microenvironment and has superior rates of engraftment.",
keywords = "angiosarcoma, tp53, tumor graft, zebrafish, zebrafish cancer model",
author = "Amanda Lipsitt and Hensch, {Nicole R.} and Rodrigo Moreno-Campos and Kunal Baxi and Jiangfei Chen and Challa, {Anil K.} and Chen, {Eleanor Y.} and Ignatius, {Myron S.}",
note = "Funding Information: This project has been funded with federal funds from NIH grant to Myron Ignatius (MI) (R00CA175184), Cancer Prevention & Research Institute of Texas (CPRIT) Scholar grant to MI (RR160062) and Max and Minnie Tomerlin Voelcker Fund Young Investigator Award (MI). Amanda Lipsitt is a recipient of postdoctoral clinical fellowship from the Cancer Prevention & Research Institute of Texas (CPRIT)-funded Research Training Award (RP 170345) and the Hyundai Hope on Wheels Young Investigator grant. Kunal Baxi is a T32 and TL1 fellow (T32CA148724, TL1TR002647). Flow cytometry data were generated in the UT Health San Antonio Flow Cytometry Shared Resource Facility, which is supported by UT Health San Antonio, the Mays Cancer Center P30 Cancer Center Support Grant (NIH-NCI P30 CA054174) and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1 TR002645. Publisher Copyright: {\textcopyright} 2021, Mary Ann Liebert, Inc., publishers.",
year = "2021",
month = aug,
doi = "10.1089/zeb.2021.0006",
language = "English (US)",
volume = "18",
pages = "293--296",
journal = "Zebrafish",
issn = "1545-8547",
publisher = "Mary Ann Liebert Inc.",
number = "4",
}