Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis

Michael G. Prouty, Nidia E. Correa, Lucia P. Barker, Pudur Jagadeeswaran, Karl E. Klose

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

We report here the development of a pathogenesis model utilizing Mycobacterium marinum infection of zebrafish (Danio rerio) for the study of mycobacterial disease. The zebrafish model mimics certain aspects of human tuberculosis, such as the formation of granuloma-like lesions and the ability to establish either an acute or a chronic infection based upon inoculum. This model allows the genetics of mycobacterial disease to be studied in both pathogen and host.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalFEMS Microbiology Letters
Volume225
Issue number2
DOIs
StatePublished - Sep 29 2003

Keywords

  • Infection model
  • Mycobacterium marinum
  • Zebrafish

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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