Z-DNA-specific antibodies in human systemic lupus erythematosus

Eileen M Lafer, R. P C Valle, A. Moller, A. Nordheim, P. H. Schur, A. Rich, B. D. Stollar

Research output: Contribution to journalArticle

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Abstract

Naturally occurring antibodies to left-handed Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies are of two types. One type reacts with both denatured DNA and Z-DNA. The other type is specific for Z-DNA and remained in the serum after removal of the cross-reactive antibody by extensive absorption on a denatured DNA affinity column. The antibodies appear to be specific for SLE and do not appear frequently in other rheumatic diseases. The presence of the antibody in SLE is correlated with the clinical manifestations of the disease, in parallel with antibodies to native and denatured DNA.

Original languageEnglish (US)
Pages (from-to)314-321
Number of pages8
JournalJournal of Clinical Investigation
Volume71
Issue number2
StatePublished - 1983
Externally publishedYes

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Z-Form DNA
Systemic Lupus Erythematosus
Antibodies
DNA
Rheumatic Diseases
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lafer, E. M., Valle, R. P. C., Moller, A., Nordheim, A., Schur, P. H., Rich, A., & Stollar, B. D. (1983). Z-DNA-specific antibodies in human systemic lupus erythematosus. Journal of Clinical Investigation, 71(2), 314-321.

Z-DNA-specific antibodies in human systemic lupus erythematosus. / Lafer, Eileen M; Valle, R. P C; Moller, A.; Nordheim, A.; Schur, P. H.; Rich, A.; Stollar, B. D.

In: Journal of Clinical Investigation, Vol. 71, No. 2, 1983, p. 314-321.

Research output: Contribution to journalArticle

Lafer, EM, Valle, RPC, Moller, A, Nordheim, A, Schur, PH, Rich, A & Stollar, BD 1983, 'Z-DNA-specific antibodies in human systemic lupus erythematosus', Journal of Clinical Investigation, vol. 71, no. 2, pp. 314-321.
Lafer EM, Valle RPC, Moller A, Nordheim A, Schur PH, Rich A et al. Z-DNA-specific antibodies in human systemic lupus erythematosus. Journal of Clinical Investigation. 1983;71(2):314-321.
Lafer, Eileen M ; Valle, R. P C ; Moller, A. ; Nordheim, A. ; Schur, P. H. ; Rich, A. ; Stollar, B. D. / Z-DNA-specific antibodies in human systemic lupus erythematosus. In: Journal of Clinical Investigation. 1983 ; Vol. 71, No. 2. pp. 314-321.
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