The effect of eradication of Helicobacter pylori on 24‐h intragastric acidity and 24‐h plasma gastrin concentration was studied in eight healthy subjects with serological evidence of H. pylori infection. Five subjects had positive urease tests, Warthin‐Starry stains of antral biopsies, and a positive 13C‐urea breath test. The other three subjects had no evidence of active H. pylori infection by these tests. All subjects were treated for 6 wk with tripotassium dicitratobismuthate (one qid) and amoxicillin (250 mg tid) with metronidazole (400 mg tid) for the 1st wk. Twenty‐four hour intragastric acidity and plasma gastrin concentration were measured before treatment, and 4–6 wk and 20–24 wk after treatment. H. pylori was eradicated in the five positive subjects, as shown by subsequent testing at the two posttreatment periods. Treatment did not affect acidity in either the H. pylori‐positive or ‐negative subjects, and did not affect the gastrin profile of the three H. pylori‐negative subjects. Eradication of H. pylori was associated with a decrease in the integrated 24‐h gastrin concentration which persisted for 20–24 wk after cessation of therapy.
|Original language||English (US)|
|Number of pages||2|
|Journal||The American Journal of Gastroenterology|
|State||Published - Dec 1991|
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