Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine

Sarah S. Bubeck, Peter H. Dube

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

Original languageEnglish (US)
Pages (from-to)1235-1238
Number of pages4
JournalClinical and Vaccine Immunology
Volume14
Issue number9
DOIs
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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