Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine

Sarah S. Bubeck, Peter H Dube

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

Original languageEnglish (US)
Pages (from-to)1235-1238
Number of pages4
JournalClinical and Vaccine Immunology
Volume14
Issue number9
DOIs
StatePublished - Sep 2007

Fingerprint

Plague Vaccine
Yersinia pestis
Attenuated Vaccines
Plague
Genes
Gene Deletion
Virulence

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine. / Bubeck, Sarah S.; Dube, Peter H.

In: Clinical and Vaccine Immunology, Vol. 14, No. 9, 09.2007, p. 1235-1238.

Research output: Contribution to journalArticle

@article{29e551e63b064ccfbc4f61479fa20158,
title = "Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine",
abstract = "An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.",
author = "Bubeck, {Sarah S.} and Dube, {Peter H}",
year = "2007",
month = "9",
doi = "10.1128/CVI.00137-07",
language = "English (US)",
volume = "14",
pages = "1235--1238",
journal = "Clinical and Vaccine Immunology",
issn = "1556-6811",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine

AU - Bubeck, Sarah S.

AU - Dube, Peter H

PY - 2007/9

Y1 - 2007/9

N2 - An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

AB - An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

UR - http://www.scopus.com/inward/record.url?scp=34948904919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34948904919&partnerID=8YFLogxK

U2 - 10.1128/CVI.00137-07

DO - 10.1128/CVI.00137-07

M3 - Article

C2 - 17652523

AN - SCOPUS:34948904919

VL - 14

SP - 1235

EP - 1238

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

SN - 1556-6811

IS - 9

ER -