Abstract
An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1235-1238 |
| Number of pages | 4 |
| Journal | Clinical and Vaccine Immunology |
| Volume | 14 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2007 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Immunology
- Immunology and Allergy
- Microbiology (medical)
Cite this
Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine. / Bubeck, Sarah S.; Dube, Peter H.
In: Clinical and Vaccine Immunology, Vol. 14, No. 9, 09.2007, p. 1235-1238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine
AU - Bubeck, Sarah S.
AU - Dube, Peter H
PY - 2007/9
Y1 - 2007/9
N2 - An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.
AB - An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.
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UR - http://www.scopus.com/inward/citedby.url?scp=34948904919&partnerID=8YFLogxK
U2 - 10.1128/CVI.00137-07
DO - 10.1128/CVI.00137-07
M3 - Article
C2 - 17652523
AN - SCOPUS:34948904919
VL - 14
SP - 1235
EP - 1238
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
SN - 1556-6811
IS - 9
ER -