Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine

Sarah S. Bubeck; Peter H. Dube

doi:10.1128/CVI.00137-07

Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine

Sarah S. Bubeck, Peter H. Dube

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

Original language	English (US)
Pages (from-to)	1235-1238
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	14
Issue number	9
DOIs	https://doi.org/10.1128/CVI.00137-07
State	Published - Sep 2007

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00137-07

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abstract = "An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92ΔyopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.",

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Yersinia pestis CO92ΔyopH is a potent live, attenuated plague vaccine

Abstract

ASJC Scopus subject areas

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