Y-Box Binding Protein 1 Regulates Angiogenesis in Bladder Cancer via miR-29b-3p-VEGFA Pathway

Dongyang Gao, Qian Niu, Yuwen Gong, Qi Guo, Su Zhang, Yuhan Wang, Shanhui Liu, Hanzhang Wang, Robert Svatek, Ronald Rodriguez, Junhai Ma, Zhiping Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Angiogenesis plays a vital role in the development of bladder cancer (BC). The Y-box-binding protein 1 (YB-1) is a well-known oncoprotein which is closely related to angiogenesis of tumors, but the relationship and mechanism of YB-1 and angiogenesis in BC remain unclear. Based on 56 clinical BC specimens, this study found that high expression of YB-1 samples demonstrated a higher expression of vascular endothelial growth factor A (VEGFA) than those of YB-1 low expression. Subsequently, the expression of YB-1 and miR-29b-3p was regulated in the BC cell lines where we noted that YB-1 promoted VEGFA expression by downregulating the expression of miR- 29b-3p. The ability of BC cells to induce angiogenesis decreased after YB-1 was knocked down. Moreover, the in vivo study further confirmed that YB-1 promotes angiogenesis in BC. Our findings enhance the understanding of how YB-1 promotes angiogenesis in BC and provide evidence for YB-1 as a therapeutic target of BC. Moreover, this may provide new inspiration for miRNAs replacement therapies.

Original languageEnglish (US)
Article number9913015
JournalJournal of Oncology
Volume2021
DOIs
StatePublished - 2021

ASJC Scopus subject areas

  • Oncology

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