Xenotransplantation and xenogeneic infections

Louisa E. Chapman; Thomas M. Folks; Daniel R. Salomon; Amy P. Patterson; Thomas E. Eggerman; Philip D. Noguchi

doi:10.1056/NEJM199511303332211

Xenotransplantation and xenogeneic infections

Louisa E. Chapman, Thomas M. Folks, Daniel R. Salomon, Amy P. Patterson, Thomas E. Eggerman, Philip D. Noguchi

Research output: Contribution to journal › Editorial › peer-review

133 Scopus citations

Abstract

The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.¹,² Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,³ and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.

Original language	English (US)
Pages (from-to)	1498-1501
Number of pages	4
Journal	New England Journal of Medicine
Volume	333
Issue number	22
DOIs	https://doi.org/10.1056/NEJM199511303332211
State	Published - Nov 30 1995

ASJC Scopus subject areas

Medicine(all)

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title = "Xenotransplantation and xenogeneic infections",

abstract = "The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,3 and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.",

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AU - Chapman, Louisa E.

AU - Folks, Thomas M.

AU - Salomon, Daniel R.

AU - Patterson, Amy P.

AU - Eggerman, Thomas E.

AU - Noguchi, Philip D.

PY - 1995/11/30

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N2 - The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,3 and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.

AB - The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,3 and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.

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