Xenotransplantation and xenogeneic infections

Louisa E. Chapman; Thomas M. Folks; Daniel R. Salomon; Amy P. Patterson; Thomas E. Eggerman; Philip D. Noguchi

doi:10.1056/NEJM199511303332211

Xenotransplantation and xenogeneic infections

Louisa E. Chapman, Thomas M. Folks, Daniel R. Salomon, Amy P. Patterson, Thomas E. Eggerman, Philip D. Noguchi

Research output: Contribution to journal › Editorial

133 Scopus citations

Abstract

The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.¹,² Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,³ and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.

Original language	English (US)
Pages (from-to)	1498-1501
Number of pages	4
Journal	New England Journal of Medicine
Volume	333
Issue number	22
DOIs	https://doi.org/10.1056/NEJM199511303332211
State	Published - Nov 30 1995

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1056/NEJM199511303332211

Fingerprint Dive into the research topics of 'Xenotransplantation and xenogeneic infections'. Together they form a unique fingerprint.

Cite this

Chapman, L. E., Folks, T. M., Salomon, D. R., Patterson, A. P., Eggerman, T. E., & Noguchi, P. D. (1995). Xenotransplantation and xenogeneic infections. New England Journal of Medicine, 333(22), 1498-1501. https://doi.org/10.1056/NEJM199511303332211

@article{e253738d1a344f81bb661a6fd7b1b436,

title = "Xenotransplantation and xenogeneic infections",

abstract = "The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,3 and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.",

author = "Chapman, {Louisa E.} and Folks, {Thomas M.} and Salomon, {Daniel R.} and Patterson, {Amy P.} and Eggerman, {Thomas E.} and Noguchi, {Philip D.}",

year = "1995",

month = nov,

day = "30",

doi = "10.1056/NEJM199511303332211",

language = "English (US)",

volume = "333",

pages = "1498--1501",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "22",

}

TY - JOUR

T1 - Xenotransplantation and xenogeneic infections

AU - Chapman, Louisa E.

AU - Folks, Thomas M.

AU - Salomon, Daniel R.

AU - Patterson, Amy P.

AU - Eggerman, Thomas E.

AU - Noguchi, Philip D.

PY - 1995/11/30

Y1 - 1995/11/30

N2 - The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,3 and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.

AB - The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans – a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,3 and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism. The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens.

UR - http://www.scopus.com/inward/record.url?scp=0028811509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028811509&partnerID=8YFLogxK

U2 - 10.1056/NEJM199511303332211

DO - 10.1056/NEJM199511303332211

M3 - Editorial

C2 - 7477153

AN - SCOPUS:0028811509

VL - 333

SP - 1498

EP - 1501

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 22

ER -